Onychomycosis
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Nail Fungus (Onychomycosis): Symptoms, Causes, and Treatment

Onychomycosis, commonly known as nail fungus, is a fungal infection that affects the nails of the hands or feet. It causes thickening, discoloration, and brittleness of the nails.

  • Prevalence: 10% of adults, 20% of the elderly.
  • Impact: While not life-threatening, it can cause discomfort, pain, and significant emotional distress.


Close-up of a thickened, discolored yellowish nail, indicative of a fungal infection (onychomycosis)
Nail Fungus

  • Causes

    The infection is caused by three groups of fungi:

    1. Dermatophytes (most common, e.g., Trichophyton rubrum)
    2. Non-dermatophytes (e.g., Fusarium, Aspergillus)
    3. Yeasts (e.g., Candida spp., more common in hands)


How is it Transmitted?

  • Fungi thrive in warm, moist environments like public showers, pools, and locker rooms.
  • Small injuries under the nail allow fungi to enter.
  • Contagion: Rare through casual contact but can spread by sharing nail tools (e.g., files, clippers).

Risk Factors 

  • Diabetes
  • Immunosuppression (e.g., HIV)
  • Aging
  • Poor circulation in the lower limbs
  • Excess moisture (e.g., athletes, tight shoes)
    Family history

Symptoms  
  • Thickened, brittle, or discolored nails
  • Nail distortion
  • Loss of shine, white patches
  • Nail separation from the skin



Types

  1. Distal Subungual: Starts at the nail tip and spreads inward.
  2. Proximal Subungual: Begins near the nail base; common in immunosuppressed patients.
  3. Superficial White: White spots appear on the surface, common in children.


Diagnosis

  • Clinical examination is insufficient; lab tests (KOH prep, PAS stain, or fungal culture) confirm the diagnosis.

Treatment

  1. Topical Treatments
    • Useful for mild cases: e.g., EfinaconazoleCiclopirox.
    • Requires long-term application (6-12 months).
  2. Oral Antifungals (Preferred for moderate to severe cases)
    • Terbinafine: 73-79% cure rate (6-12 weeks).
    • Itraconazole: Alternative to terbinafine.
  3. Other Treatments
    • Laser Therapy & Photodynamic Therapy: Promising but lack strong evidence.
    • Surgical Removal: Reserved for severe, non-responsive cases.

Prevention & Reinfection

  • Keep feet clean and dry.
  • Avoid walking barefoot in public areas.
  • Disinfect nail tools regularly.



Key Takeaway

Onychomycosis is common, treatable, but requires persistence. Early diagnosis and appropriate treatment—topical or oral antifungals—are key to recovery and preventing recurrence.